Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474781 | 0.86 | RET (0.50) | RETGSK3BNOX4TLK2FLT3 | |
| SCHEMBL7473364 | 0.82 | RET (0.47) | RETGSK3BNOX4TLK2FLT3 | |
| SCHEMBL7473409 | 0.82 | TLK2 (0.44) | RETGSK3BTLK2PDPK1BRD4 | |
| SCHEMBL7476129 | 0.82 | RET (0.43) | RETGSK3BNOX4LRRK2TLK2 | |
| SCHEMBL7475417 | 0.81 | RET (0.44) | RETGSK3BNOX4TLK2FLT3 | |
| SCHEMBL7480965 | 0.81 | RET (0.45) | RETGSK3BTLK2FLT3FLT4 | |
| SCHEMBL7475213 | 0.81 | RET (0.43) | RETGSK3BLRRK2TLK2BRD4 | |
| SCHEMBL7479489 | 0.81 | RET (0.42) | RETGSK3BNOX4LRRK2TLK2 | |
| SCHEMBL7476920 | 0.80 | RET (0.45) | RETGSK3BNOX4TLK2FLT3 | |
| SCHEMBL7481674 | 0.80 | RET (0.41) | RETGSK3BNOX4TLK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |