Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.43 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474781 | 0.83 | RET (0.50) | RETTLK2BRD4GSK3B | |
| SCHEMBL7480965 | 0.82 | RET (0.45) | RETTLK2BRD4NTRK1NTRK3 | |
| SCHEMBL7474878 | 0.82 | ACHE (0.42) | RETTLK2CHEK1 | |
| SCHEMBL7479489 | 0.82 | RET (0.42) | RETTLK2BRD4CHEK1ALK | |
| SCHEMBL7475792 | 0.82 | RET (0.48) | RETTLK2BRD4NTRK1 | |
| SCHEMBL7472918 | 0.81 | RET (0.54) | RETTLK2BRD4LRRK2NTRK3 | |
| SCHEMBL6337433 | 0.80 | RET (0.43) | RETTLK2BRD4CHEK1LRRK2 | |
| SCHEMBL7473364 | 0.80 | RET (0.47) | RETTLK2BRD4CHEK1MAPT | |
| SCHEMBL7473409 | 0.80 | TLK2 (0.44) | RETTLK2BRD4CHEK1NTRK1 | |
| SCHEMBL7476920 | 0.80 | RET (0.45) | RETTLK2BRD4ALKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |