Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 8/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606045 | 0.95 | KCNE1 (0.53) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL7472128 | 0.94 | KCNE1 (0.48) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL7466032 | 0.88 | KCNE1 (0.48) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL8483181 | 0.87 | KCNE1 (0.56) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL6602411 | 0.86 | KCNE1 (0.56) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL7475926 | 0.84 | KCNE1 (0.54) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL8476685 | 0.84 | KCNE1 (0.53) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL8481451 | 0.84 | KCNE1 (0.49) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL6601750 | 0.83 | KCNE1 (0.43) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL7470000 | 0.83 | KCNE1 (0.56) | KCNE1KCNQ1MAOBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |