Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2757925 | 0.80 | LMNA (0.60) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL3118731 | 0.78 | LMNA (0.58) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL12788486 | 0.77 | LMNA (0.56) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL13887704 | 0.77 | LMNA (0.56) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL5150 | 0.76 | POLB (0.68) | SMN1; SMN2POLBKMT2A | |
| SCHEMBL823974 | 0.75 | HTT (0.55) | LMNASMN1; SMN2GAA | |
| SCHEMBL20328072 | 0.75 | LMNA (0.55) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL6628000 | 0.75 | LMNA (0.55) | LMNASMN1; SMN2GAAPOLBKMT2A | |
| SCHEMBL12788665 | 0.73 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL22642321 | 0.73 | LMNA (0.53) | LMNASMN1; SMN2GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |