SCHEMBL7473559

SCHEMBL7473559

O=C(O)c1cccc2[nH]c(-c3ccccn3)nc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 11/20 0.64
PARP1 P09874 3/20 0.64
PARP2 Q9UGN5 1/20 0.64
CBFB Q13951 4/20 0.62
HPGD P15428 3/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
ALDH1A1 P00352 2/20 0.58
TP53 P04637 2/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
ALOX15 P16050 1/20 0.58
CYP2C19 P33261 1/20 0.58
HSD17B10 Q99714 1/20 0.58
METAP2 P50579 2/20 0.56
METAP1 P53582 2/20 0.56
NPC1 O15118 2/20 0.55
RAB9A P51151 2/20 0.55
KDM4E B2RXH2 1/20 0.55
MAPT P10636 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6805503 0.88 PARP1 (0.81) DHODHPARP1PARP2CBFB
SCHEMBL1298102 0.84 DHODH (0.65) DHODHPARP1HPGDKDM4E
SCHEMBL9725333 0.83 DHODH (0.77) DHODHPARP1HPGDKDM4E
SCHEMBL1298745 0.82 DHODH (0.59) DHODHPARP1HPGDKDM4E
SCHEMBL7475607 0.81 CBFB (0.63) DHODHPARP1PARP2CBFBHPGD
SCHEMBL1298432 0.81 DHODH (0.94) DHODHPARP1
SCHEMBL1202741 0.80 DHODH (0.60) DHODHPARP1
SCHEMBL1298168 0.79 DHODH (0.59) DHODHPARP1CBFBALOX15
SCHEMBL1297761 0.79 DHODH (0.52) DHODHPARP1
SCHEMBL1889016 0.78 DHODH (0.59) DHODHPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-0946519-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
WO-1998024771-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-11 WO disclosed