Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.81 |
| ▸ | DHODH | Q02127 | 2/20 | 0.81 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.81 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.64 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.64 |
| ▸ | PRKACA | P17612 | 1/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.64 |
| ▸ | CLK2 | P49760 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660169 | 0.88 | PARP1 (0.71) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL7473559 | 0.88 | DHODH (0.64) | PARP1DHODHPARP2CBFB | |
| SCHEMBL6805003 | 0.84 | PKN1 (0.67) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL6805347 | 0.81 | PARP1 (0.63) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL6585381 | 0.81 | CBFB (0.67) | PARP1DHODHPARP2CBFB | |
| SCHEMBL6806558 | 0.81 | ADORA3 (0.63) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL7475607 | 0.80 | CBFB (0.63) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL458836 | 0.80 | PARP1 (1.00) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL29412034 | 0.80 | PARP1 (1.00) | PARP1DHODHPARP2PKN1PKN2 | |
| SCHEMBL658269 | 0.80 | PARP1 (0.70) | PARP1DHODHPARP2PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101353342-A | 2-pyridinyl-1H-benzimidazole-4-acidamide type derivative | UNIV SHANGHAI JIAOTONG (CN) | 2009-01-28 | — | — | CN | disclosed |
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |