Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416386 | 0.93 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL2236956 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL7532781 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10MAPTHDAC1 | |
| SCHEMBL7427803 | 0.85 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL12348380 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL7424707 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL18737831 | 0.75 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10MAPTHDAC1 | |
| SCHEMBL2233293 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL7707267 | 0.74 | ALDH1A1 (0.61) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL146498 | 0.73 | KMT2A (0.41) | ALDH1A1KDM4EHDAC1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |