Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957257 | 0.84 | LMNA (0.48) | SLC6A4SLC6A2SLC6A3LMNAMEN1 | |
| SCHEMBL3150352 | 0.84 | LMNA (0.48) | SLC6A4SLC6A2SLC6A3LMNAMEN1 | |
| Ortho-Phthalaldehyde SCHEMBL2474511 | 0.82 | LMNA (0.52) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL10736369 | 0.79 | LMNA (0.38) | LMNAMEN1THRBBLMKMT2A | |
| Ethylene SCHEMBL8381763 | 0.77 | LMNA (0.33) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL11323911 | 0.75 | LMNA (0.40) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL6918730 | 0.75 | LMNA (0.40) | LMNAMEN1THRBBLMKMT2A | |
| Salicyladehyde SCHEMBL6903346 | 0.75 | TRIM24 (0.60) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL3905460 | 0.75 | LMNA (0.40) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL7568179 | 0.75 | MEN1 (0.43) | LMNAMEN1KMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |