Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468739 | 0.87 | PDE5A (0.46) | PDE5AMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7462823 | 0.85 | STAT1 (0.51) | PDE5AMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7473397 | 0.85 | PDE5A (0.59) | PDE5AMEN1KMT2ACLK4ALDH1A1 | |
| SCHEMBL7465102 | 0.84 | PDE5A (0.54) | PDE5AMEN1KMT2APDE2APDE1A | |
| SCHEMBL7465985 | 0.82 | PDE5A (0.55) | PDE5AMEN1KMT2ACLK4ALDH1A1 | |
| SCHEMBL7466276 | 0.82 | MAPK1 (0.56) | MEN1KMT2ACLK4ALDH1A1LMNA | |
| SCHEMBL7460966 | 0.81 | STAT1 (0.45) | PDE5AMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7459198 | 0.81 | MEN1 (0.53) | PDE5AMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7468592 | 0.80 | PDE5A (0.52) | PDE5AMEN1KMT2ACLK4ALDH1A1 | |
| SCHEMBL7468081 | 0.80 | KMT2A (0.42) | PDE5AMEN1KMT2ACLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |