Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470701 | 0.84 | PDE5A (0.56) | PDE5AMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7474339 | 0.84 | PDE5A (0.48) | PDE5AMEN1KMT2APDE2APDE1A | |
| SCHEMBL7475093 | 0.83 | PDE5A (0.68) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7473060 | 0.82 | STAT1 (0.64) | PDE5AMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7474841 | 0.80 | PDE5A (0.48) | PDE5AMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7470465 | 0.78 | MAPK1 (0.66) | MEN1KMT2AMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7474668 | 0.78 | HTT (0.63) | PDE5AMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7474799 | 0.77 | PDE5A (0.59) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7465501 | 0.77 | STAT1 (0.56) | PDE5AMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7473136 | 0.76 | STAT1 (0.52) | PDE5AMEN1KMT2AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |