Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 11/20 | 0.73 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.73 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.73 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.73 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.73 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.73 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.73 |
| ▸ | CCKBR | P32239 | 2/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | GABRP | O00591 | 2/20 | 0.57 |
| ▸ | GABRD | O14764 | 2/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.57 |
| ▸ | GABRE | P78334 | 2/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.57 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.57 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.57 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353127 | 0.87 | GABRA1 (0.82) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL9238180 | 0.85 | GABRA1 (0.79) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL877728 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL30175096 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11612769 | 0.84 | GABRA1 (0.68) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL4817228 | 0.83 | GABRA1 (0.73) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| Ro-054520 SCHEMBL11858895 | 0.80 | GABRA1 (0.70) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL5038185 | 0.78 | GABRA1 (0.68) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL14212131 | 0.77 | GABRA1 (0.79) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL27567875 | 0.77 | GABRA1 (0.73) | GABRA1GABRA5GABRA2GABRA3GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951466-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998028268-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 1998-07-02 | — | — | WO | disclosed |