Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407484 | 0.81 | CRHR1 (0.46) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7479803 | 0.76 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL7482395 | 0.76 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6199707 | 0.75 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL6204481 | 0.75 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL7473836 | 0.73 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL7482393 | 0.73 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7474054 | 0.71 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL7475184 | 0.70 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL7599447 | 0.69 | CRHR1 (0.39) | CRHR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |