SCHEMBL747461

SCHEMBL747461

COc1cccc(CN(C)C(C=O)c2ccc(Cl)c(Cl)c2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.44
MEN1 O00255 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.41
ALDH1A1 P00352 2/20 0.41
LMNA P02545 2/20 0.41
CALM1 P0DP23 1/20 0.40
CAMKK2 Q96RR4 1/20 0.40
KDM4E B2RXH2 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PKM P14618 1/20 0.39
HSD17B2 P37059 1/20 0.39
DPP4 P27487 1/20 0.39
AOC3 Q16853 1/20 0.39
CHRM5 P08912 1/20 0.38
CHRM2 P08172 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
TAAR1 Q96RJ0 2/20 0.38
BCHE P06276 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL747464 0.80 KMT2A (0.42) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA
SCHEMBL747463 0.75 KMT2A (0.54) KMT2AMEN1SMN1; SMN2ALDH1A1CALM1
SCHEMBL7809517 0.75 TACR1 (0.47) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA
Hydrochloric Acid SCHEMBL11794630 0.74 KMT2A (0.53) KMT2AMEN1SMN1; SMN2ALDH1A1CALM1
SCHEMBL7807768 0.73 TACR1 (0.44) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA
SCHEMBL7809340 0.72 TACR1 (0.51) KMT2AMEN1SMN1; SMN2HSD17B2BCHE
SCHEMBL7811348 0.71 TACR1 (0.47) KMT2AMEN1SMN1; SMN2HSD17B2DPP4
SCHEMBL21426199 0.69 TAAR1 (0.46) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA
SCHEMBL11796383 0.69 PLA2G1B (0.56) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA
SCHEMBL7809519 0.69 MEN1 (0.45) KMT2AMEN1SMN1; SMN2HSD17B2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2429293-A1 CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF Bristol-Myers Squibb Company (US) 2012-03-21 EP disclosed
EP-2429296-A1 7-([1,2,4,]TRIAZOLO[1,5,-A]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4- TETRAHYDROISOQUINOLINE AND USE THEREOF Albany Molecular Research, Inc. (US) 2012-03-21 EP disclosed
EP-2429295-A1 ARYL, HETEROARYL, AND HETEROCYCLE SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF Albany Molecular Research, Inc. (US) 2012-03-21 EP disclosed
WO-2010132442-A1 7-([1,2,4,]TRIAZOLO[1,5,-A]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4- TETRAHYDROISOQUINOLINE AND USE THEREOF ALBANY MOLECULAR RESERCH, INC. (US) 2010-11-18 WO disclosed
WO-2010132437-A1 ARYL, HETEROARYL, AND HETEROCYCLE SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2010-11-18 WO disclosed
WO-2010132487-A1 CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2010-11-18 WO disclosed