Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 5/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802828 | 0.91 | TACR1 (0.56) | TACR1TDP1SMN1; SMN2 | |
| SCHEMBL7809340 | 0.89 | TACR1 (0.51) | TACR1HSD17B2TDP1TSPOMEN1 | |
| SCHEMBL7809517 | 0.87 | TACR1 (0.47) | TACR1HSD17B2TDP1TSPODPP4 | |
| SCHEMBL7815209 | 0.86 | TACR1 (0.50) | TACR1TDP1MEN1KMT2AHPGD | |
| SCHEMBL7807768 | 0.85 | TACR1 (0.44) | TACR1HSD17B2TDP1TSPODPP4 | |
| SCHEMBL7807544 | 0.82 | KDM4E (0.45) | TDP1 | |
| SCHEMBL6973685 | 0.81 | MEN1 (0.47) | TACR1TDP1MEN1KMT2ABCHE | |
| SCHEMBL7811515 | 0.81 | ALDH1A1 (0.55) | TACR1BCHESMN1; SMN2POLBHPGD | |
| SCHEMBL7815520 | 0.79 | TACR1 (0.60) | TACR1TDP1SMN1; SMN2 | |
| SCHEMBL7815376 | 0.78 | FFAR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |