Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474653 | 1.00 | CYP1A2 (0.39) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11277749 | 1.00 | CYP1A2 (0.39) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5847912 | 0.82 | CYP1A2 (0.35) | CYP1A2CYP2C19ALDH1A1LMNAHPGD | |
| SCHEMBL5847915 | 0.82 | CYP1A2 (0.35) | CYP1A2CYP2C19ALDH1A1LMNAHPGD | |
| SCHEMBL6835112 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10717796 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7477373 | 0.81 | SMN1; SMN2 (0.44) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7477379 | 0.81 | SMN1; SMN2 (0.44) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6835113 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7483238 | 0.77 | SMN1; SMN2 (0.39) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150307520-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS THEREOF | HUTCHISON MEDIPHARMA LTD (CN) | 2015-10-29 | — | — | US | disclosed |
| US-20150291593-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | HUTCHISON MEDIPHARMA LTD (CN) | 2015-10-15 | — | — | US | disclosed |
| EP-2877472-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF | Hutchison Medipharma Limited (CN) | 2015-06-03 | — | — | EP | disclosed |
| WO-2014015830-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-01-30 | — | — | WO | disclosed |
| WO-2014015675-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-01-30 | — | — | WO | disclosed |
| EP-1219608-A1 | PYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-4316847-A | ARTIFICIAL SWEETENING | HOFFMANN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| US-4256641-A | ALKYL ALPHA-CARBOXAMIDOINDOLE-3-ACRYLATES MADE FROM 3-INDOLECARBOXALDEHYDES AND MONOALKYL CARBOXAMIDOMALONATES | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4140697-A | ARTIFICIAL SWEETENER | HOFFMANN-LA ROCHE INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4073795-A | Synthesis of tryptophans | HOFFMANN-LA ROCHE INC. (US) | 1978-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307520-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS THEREOF | PIK3C3, PIK3C2B, PIK3C2A | CYP1A2 432/4885CYP2C19 748/4885SMN1; SMN2 4323/4885 |
| US-20150291593-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | PIK3C2B, PIK3C3, PIK3C2A | CYP1A2 476/4885CYP2C19 853/4885SMN1; SMN2 3786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.