Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5523102 | 0.85 | NCF1 (0.72) | NCF1KMT2AMEN1CKS1BSKP1 | |
| SCHEMBL7467892 | 0.83 | MAP4K4 (0.51) | MAP4K4KMT2AMEN1SMARCA2SMARCA4 | |
| SCHEMBL7471109 | 0.83 | MAPT (0.59) | NCF1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5759182 | 0.80 | NCF1 (0.52) | NCF1MAP4K4KMT2AMEN1SMARCA2 | |
| SCHEMBL29569426 | 0.78 | NR1H2 (0.54) | MAP4K4KMT2AMEN1SMARCA2SMARCA4 | |
| SCHEMBL116544 | 0.78 | NR1H2 (0.54) | MAP4K4KMT2AMEN1SMARCA2SMARCA4 | |
| SCHEMBL5383294 | 0.78 | NR1H2 (0.54) | MAP4K4KMT2AMEN1SMARCA2SMARCA4 | |
| SCHEMBL7472712 | 0.78 | MAP4K4 (0.48) | MAP4K4KMT2AMEN1SMARCA2SMARCA4 | |
| SCHEMBL6308917 | 0.78 | BACE1 (0.51) | MAP4K4SMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL16417060 | 0.78 | KIT (0.48) | MAP4K4SMARCA2SMARCA4PBRM1CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |