Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.52 |
| ▸ | CTSL | P07711 | 8/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362103 | 0.88 | CTSS (0.65) | CTSSCTSLCTSB | |
| SCHEMBL5362109 | 0.88 | CTSS (0.65) | CTSSCTSLCTSB | |
| SCHEMBL7478292 | 0.87 | CTSS (0.53) | CTSSCTSLCTSBCTSK | |
| SCHEMBL6107975 | 0.86 | CTSS (0.60) | CTSSCTSL | |
| SCHEMBL6105630 | 0.83 | CTSS (0.43) | CTSSCTSLCTSK | |
| SCHEMBL5366939 | 0.82 | CTSS (0.52) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5366935 | 0.82 | CTSS (0.52) | CTSSCTSLCTSBCTSK | |
| SCHEMBL6964964 | 0.82 | CTSS (0.53) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5357536 | 0.81 | CTSS (0.66) | CTSSCTSLCTSB | |
| SCHEMBL5357539 | 0.81 | CTSS (0.66) | CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |