Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475075 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1HPGDPKMJAK3 | |
| SCHEMBL7475088 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1HPGDPKMJAK3 | |
| Water SCHEMBL7483553 | 0.82 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDPKMJAK3 | |
| Water SCHEMBL7483554 | 0.82 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDPKMJAK3 | |
| SCHEMBL7479674 | 0.79 | POLB (0.51) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7479665 | 0.79 | POLB (0.51) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL11715411 | 0.73 | F7 (0.53) | ALDH1A1ADORA2AADORA1HDAC1F7 | |
| SCHEMBL4026120 | 0.68 | CGAS (0.65) | KDM4EALDH1A1HPGDPKMCGAS | |
| SCHEMBL1242243 | 0.67 | ALDH1A1 (0.71) | ALDH1A1HDAC1F7F3SARM1 | |
| SCHEMBL29915528 | 0.67 | ALDH1A1 (0.71) | ALDH1A1HDAC1F7F3SARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541153-A1 | 1,3-Dihydro-2H-imidazo[4,5-b]-quinolin-2-one derivatives as phosphodiesterase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-12 | — | — | EP | disclosed |