Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169948 | 0.84 | PTGS2 (0.73) | PTGS2PTGS1GPR17 | |
| SCHEMBL6170778 | 0.83 | PTGS2 (0.76) | PTGS2PTGS1GPR17 | |
| SCHEMBL6171284 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1GPR17 | |
| SCHEMBL6168380 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1GPR17 | |
| SCHEMBL6169936 | 0.81 | PTGS2 (0.70) | PTGS2PTGS1MCL1GPR17 | |
| SCHEMBL6170571 | 0.80 | PTGS2 (0.71) | PTGS2PTGS1GPR17 | |
| SCHEMBL6170181 | 0.78 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL6171586 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1GPR17 | |
| SCHEMBL6171550 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1GPR17 | |
| SCHEMBL6170896 | 0.77 | PTGS2 (0.64) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065204-B1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER (US) | 2002-04-10 | — | — | EP | claimed |
| US-6303628-B1 | FOR THE TREATMENT OF A MEDICAL CONDITION IN WHICH PROSTAGLANDINS ARE IMPLICATED AS PATHOGENS IN MAMMALS | PFIZER INC | 2001-10-16 | — | — | US | claimed |
| EP-1065204-A1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER INC. (US) | 2001-01-03 | — | — | EP | claimed |
| EP-1065204-B1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6303628-B1 | FOR THE TREATMENT OF A MEDICAL CONDITION IN WHICH PROSTAGLANDINS ARE IMPLICATED AS PATHOGENS IN MAMMALS | PFIZER INC | 2001-10-16 | — | — | US | disclosed |
| EP-1065204-A1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |