Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962351 | 0.93 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BMAPTALDH1A1 | |
| SCHEMBL7475346 | 0.91 | MAP3K7 (0.32) | AVPR2AVPR1AAVPR1BRXFP1BRPF1 | |
| SCHEMBL7478403 | 0.85 | — | — | |
| SCHEMBL7973515 | 0.83 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BMAPTRXFP1 | |
| SCHEMBL7967301 | 0.82 | AVPR2 (0.35) | AVPR2AVPR1AAVPR1BMAPTRXFP1 | |
| Hydrochloric Acid SCHEMBL7971911 | 0.82 | MAP3K7 (0.35) | AVPR2AVPR1AAVPR1BBRPF1MAP3K7 | |
| SCHEMBL7973561 | 0.81 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAPTRXFP1 | |
| SCHEMBL7964892 | 0.81 | AVPR2 (0.35) | AVPR2AVPR1AAVPR1BMAPTRXFP1 | |
| SCHEMBL7474244 | 0.81 | AVPR2 (0.33) | AVPR2AVPR1AAVPR1BRXFP1MAP3K7 | |
| SCHEMBL7476168 | 0.80 | MAP3K7 (0.34) | AVPR2AVPR1AAVPR1BALDH1A1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |