SCHEMBL7475229

SCHEMBL7475229

O=C(O)Cc1cccc(CC(=O)c2ccccc2)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.59
MAPT P10636 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
SRD5A2 P31213 2/20 0.53
HPSE Q9Y251 1/20 0.49
NR4A2 P43354 1/20 0.48
TDP1 Q9NUW8 2/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
CYP3A4 P08684 1/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
CES1 P23141 1/20 0.48
MAPK1 P28482 1/20 0.48
KMT2A Q03164 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
RAB9A P51151 2/20 0.47
GAA P10253 2/20 0.47
NPC1 O15118 1/20 0.47
CASP3 P42574 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11633589 0.94 MAPT (0.60) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL16171152 0.87 MAPT (0.53) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL70565 0.85 AKR1B1 (0.71) AKR1B1MAPTHPSETDP1KDM4E
SCHEMBL1515921 0.85 MAPT (0.51) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL27625881 0.85 LOXL2 (0.51) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL13381372 0.85 SRD5A2 (0.62) MAPTL3MBTL1SRD5A2NR4A2KMT2A
Hydrochloric Acid SCHEMBL27462374 0.84 LOXL2 (0.50) MAPTL3MBTL1SRD5A2RAB9AGAA
SCHEMBL24800 0.83 MAPT (0.73) AKR1B1MAPTL3MBTL1SRD5A2NR4A2
Hydrochloric Acid SCHEMBL8922940 0.83 AKR1B1 (0.68) AKR1B1MAPTHPSETDP1KDM4E
SCHEMBL1515758 0.83 SRD5A2 (0.61) MAPTL3MBTL1SRD5A2NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019055942-A1 METHODS AND COMPOSITIONS TO INHIBIT TOLERANCE TO OPIOIDS SEN-JAM Pharmaceutical LLC (US) 2019-03-21 WO disclosed
EP-0821589-A4 COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS NITROMED INC (US) 2002-05-15 EP disclosed
WO-2001062085-A1 PROTECTED FORMS OF PHARMACOLOGICALLY ACTIVE AGENTS AND USES THEREFOR MEDINOX, INC. (US) 2001-08-30 WO disclosed
EP-0821589-A1 COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS Nitromed, Inc. (US) 1998-02-04 EP disclosed
WO-1996032946-A1 COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS NITROMED, INC. (US) 1996-10-24 WO disclosed