Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.74 |
| ▸ | PTPRC | P08575 | 7/20 | 0.74 |
| ▸ | PTPRF | P10586 | 2/20 | 0.74 |
| ▸ | CDC25B | P30305 | 2/20 | 0.74 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL7487471 | 0.86 | PTPN1 (0.85) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL29808966 | 0.86 | PTPN1 (1.00) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL6236312 | 0.86 | PTPN1 (1.00) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL4192820 | 0.75 | PTPN1 (0.61) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL30433091 | 0.74 | PTPN1 (0.76) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL5139479 | 0.74 | PTPN1 (0.76) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL8600693 | 0.74 | PTPN1 (0.75) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL6236908 | 0.74 | PTPRC (1.00) | PTPN1PTPRCPTPRFCDC25BBACE1 | |
| SCHEMBL7487467 | 0.72 | PTPN1 (0.67) | PTPN1PTPRCPTPRFCDC25B | |
| SCHEMBL29673492 | 0.71 | BACE1 (1.00) | PTPN1PTPRCPTPRFCDC25BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025107-B1 | PHOTOCHROMIC COMPOUNDS | JAMES ROBINSON LTD (GB) | 2002-08-07 | — | — | EP | disclosed |
| US-6303673-B1 | FOR OPTICAL ELEMENTS | JAMES ROBINSON LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |