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SCHEMBL7475336

SCHEMBL7475336

Nc1nccc2ccc(OC(C(=O)Nc3ccc(-c4ccccc4S(N)(=O)=O)cc3)c3ccccc3)cc12

nearest known ligand 0.63

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 20/20 0.63
▸ PRSS1 P07477 5/20 0.63
▸ F2 P00734 3/20 0.56
▸ PRSS2 P07478 1/20 0.56
▸ PRSS3 P35030 1/20 0.56
▸ PLG P00747 1/20 0.49
▸ PROC P04070 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7476586 0.93 F10 (0.57) F10PRSS1F2PRSS2PRSS3
SCHEMBL7472782 0.93 F10 (0.57) F10PRSS1F2PRSS2PRSS3
SCHEMBL7482436 0.88 F10 (0.57) F10PRSS1F2PRSS2PRSS3
SCHEMBL7481963 0.88 F10 (0.65) F10PRSS1F2PRSS2PRSS3
SCHEMBL7476336 0.88 F10 (0.66) F10PRSS1F2PRSS2PRSS3
SCHEMBL7479772 0.88 F10 (0.61) F10PRSS1F2PRSS2PRSS3
SCHEMBL7133162 0.84 F10 (0.64) F10PRSS1F2PRSS2PRSS3
SCHEMBL7448169 0.83 F10 (0.57) F10PRSS1F2PRSS2PRSS3
Trifluoroacetic Acid SCHEMBL7080631 0.83 F10 (0.56) F10PRSS1F2PRSS2PRSS3
SCHEMBL7076322 0.81 F10 (0.51) F10PRSS1F2PRSS2PRSS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1183235-A2 INHIBITORS OF FACTOR Xa COR THERAPEUTICS, INC. (US) 2002-03-06 — — EP disclosed
WO-2000071510-A2 INHIBITORS OF FACTOR Xa COR THERAPEUTICS, INC. (US) 2000-11-30 — — WO disclosed