Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471291 | 0.83 | CTSB (0.38) | MEN1KMT2AKDM4ETDP1POLB | |
| SCHEMBL7483015 | 0.82 | MEN1 (0.54) | MEN1KMT2AKDM4ETDP1POLB | |
| SCHEMBL7475376 | 0.79 | MEN1 (0.48) | MEN1KMT2AKDM4ETDP1POLB | |
| SCHEMBL19170937 | 0.74 | HSD17B10 (0.51) | MEN1KMT2AKDM4EMAPTNQO2 | |
| SCHEMBL6543963 | 0.74 | PKN1 (0.55) | MEN1KMT2AKDM4ETDP1MAPT | |
| SCHEMBL13542759 | 0.73 | GRIN2D (0.47) | — | |
| SCHEMBL7478041 | 0.73 | KCNH2 (0.47) | L3MBTL1MAPTPDE4APDE4BPDE4C | |
| SCHEMBL7473230 | 0.72 | KDM4E (0.46) | MEN1KMT2AKDM4ETDP1POLB | |
| SCHEMBL7473228 | 0.72 | KDM4E (0.46) | MEN1KMT2AKDM4ETDP1POLB | |
| SCHEMBL22761576 | 0.70 | PDE4A (0.52) | MEN1KMT2AKDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0865281-A4 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 1999-07-28 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0865281-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021437-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (DE) | 1997-06-19 | — | — | WO | disclosed |