Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5973099 | 1.00 | RORC (0.40) | RORCGPR119ESR2HSD17B10GRM5 | |
| SCHEMBL830155 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL30700513 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL29063356 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL4198304 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL2299757 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL14343619 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL15185071 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL1595217 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E | |
| SCHEMBL830156 | 0.90 | RORC (0.46) | RORCGPR119GRM5TACR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914332-B1 | ISOQUINOLINES USEFUL AS ANALGESICS | ASTRAZENECA AB (SE) | 2002-05-08 | — | — | EP | disclosed |
| US-6034097-A | Isoquinolines useful as analgesics | ASTRA AB (SE) | 2000-03-07 | — | — | US | disclosed |