Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.43 |
| ▸ | DHODH | Q02127 | 8/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475096 | 0.75 | PARP1 (0.45) | PARP1DHODHCHEK2HPSE | |
| SCHEMBL6588173 | 0.75 | PARP1 (0.49) | PARP1DHODHCHEK2PDE5AHPSE | |
| SCHEMBL6590617 | 0.73 | PARP1 (0.48) | PARP1DHODHCHEK2HPSE | |
| SCHEMBL6591546 | 0.73 | PARP1 (0.44) | PARP1DHODHCHEK2HPSE | |
| SCHEMBL6589916 | 0.73 | TUBB4A (0.44) | PARP1DHODHCHEK2HPSE | |
| SCHEMBL6586775 | 0.72 | PARP1 (0.46) | PARP1DHODHCHEK2HPSE | |
| SCHEMBL6585207 | 0.71 | PARP1 (0.51) | PARP1DHODHCHEK2HPSE | |
| SCHEMBL7479706 | 0.70 | PARP1 (0.49) | PARP1PDE5AHPSE | |
| SCHEMBL7480486 | 0.70 | PARP1 (0.46) | PARP1DHODHCHEK2PDE5AHPSE | |
| SCHEMBL6585381 | 0.70 | CBFB (0.67) | PARP1DHODHPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |