Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480371 | 0.87 | CYP1A2 (0.49) | MAPTLMNAHTTCYP1A2CYP3A4 | |
| SCHEMBL5811682 | 0.81 | MAOA (0.47) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| SCHEMBL2771388 | 0.77 | AOC3 (0.49) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| Hydrochloric Acid SCHEMBL2768923 | 0.76 | AOC3 (0.51) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| SCHEMBL30417592 | 0.73 | NPSR1 (0.48) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| SCHEMBL7677829 | 0.73 | NPSR1 (0.48) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| SCHEMBL11115687 | 0.71 | MAPT (0.60) | L3MBTL1MAPK1MAPTTDP1ALDH1A1 | |
| SCHEMBL7481745 | 0.70 | CYP1A2 (0.51) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| SCHEMBL8112364 | 0.69 | EGFR (0.36) | L3MBTL1MAPK1MAPTTDP1LMNA | |
| SCHEMBL7487573 | 0.69 | CYP1A2 (0.57) | L3MBTL1MAPK1MAPTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |