SCHEMBL7476573

SCHEMBL7476573

Cc1c(N)c(N)cc(Cl)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD44 P16070 1/20 0.48
GAA P10253 3/20 0.46
ALDH1A1 P00352 6/20 0.43
MAPT P10636 1/20 0.43
CYP3A4 P08684 9/20 0.36
TSHR P16473 5/20 0.36
PIK3CA P42336 1/20 0.36
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
NPC1 O15118 1/20 0.32
TP53 P04637 1/20 0.32
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA3 P07451 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3672177 0.82 CD44 (0.50) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL23205869 0.82 CD44 (0.50) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL11562840 0.82 ALDH1A1 (0.45) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL11795237 0.80 ALDH1A1 (0.59) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL11055289 0.80 CD44 (0.48) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL6352273 0.80 ALDH1A1 (0.48) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL9251854 0.77 CD44 (0.50) CD44GAAALDH1A1MAPTCYP3A4
SCHEMBL7210094 0.76 GAA (0.53) CD44GAAALDH1A1CYP3A4TSHR
SCHEMBL8321419 0.76 GAA (0.53) CD44GAAALDH1A1CYP3A4TSHR
SCHEMBL10976016 0.75 CD44 (0.48) CD44GAAALDH1A1MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783495-B1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY PFIZER LTD (GB) 2002-02-27 EP disclosed
EP-0781279-B1 QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS PFIZER LTD (GB) 2001-06-13 EP disclosed
US-5852016-A Quinoxaline derivatives useful in therapy PFIZER INC. (US) 1998-12-22 US disclosed
US-5783572-A TREATMENT OF NEURODEGENERATIVE DISORDERS PFIZER INC. (US) 1998-07-21 US disclosed
EP-0783495-A1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY Pfizer Limited (GB) 1997-07-16 EP disclosed
EP-0781279-A1 QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS Pfizer Limited (GB) 1997-07-02 EP disclosed
WO-1996009295-A1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY PFIZER LIMITED (GB) 1996-03-28 WO disclosed
WO-1996008485-A1 QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS PFIZER LIMITED (GB) 1996-03-21 WO disclosed