Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463468 | 0.90 | ALDH1A1 (0.55) | HTTPOLBTP53ALDH1A1CYP1A2 | |
| SCHEMBL17803672 | 0.88 | ALDH1A1 (0.47) | HTTTP53ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17806464 | 0.83 | HTT (0.42) | HTTTP53ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7460757 | 0.82 | CYP1A2 (0.64) | HTTPOLBTP53CYP1A2SMN1; SMN2 | |
| SCHEMBL8636262 | 0.82 | KMT2A (0.46) | HTTPOLBALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL7476695 | 0.82 | HTT (0.48) | HTTPOLBTP53ALDH1A1CYP1A2 | |
| SCHEMBL26757977 | 0.82 | HTT (0.56) | HTTPOLBALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL17806470 | 0.81 | MEN1 (0.43) | HTTPOLBTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL5713303 | 0.80 | HTT (0.54) | HTTPOLBALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL18770223 | 0.79 | HTT (0.53) | HTTPOLBALDH1A1CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |