Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5434549 | 0.86 | NR4A2 (0.69) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL29805074 | 0.85 | NR4A2 (0.64) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL5176370 | 0.82 | HPGD (0.46) | NR4A2 | |
| SCHEMBL30622613 | 0.82 | KDM4E (0.55) | MTNR1AMTNR1BSMN1; SMN2SLC6A4GPR84 | |
| SCHEMBL24243764 | 0.82 | KDM4E (0.55) | MTNR1AMTNR1BSMN1; SMN2SLC6A4GPR84 | |
| SCHEMBL31127577 | 0.81 | NR4A2 (0.63) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL1557691 | 0.81 | NR4A2 (0.63) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL8917164 | 0.81 | NR4A2 (0.50) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL31748335 | 0.80 | NR4A2 (0.61) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL1558405 | 0.80 | NR4A2 (0.61) | NR4A2GABRA1GABRB1GABRA3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975594-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LTD (GB) | 2002-09-18 | — | — | EP | disclosed |
| US-6281357-B1 | HEADACHE THERAPY | PFIZER INC | 2001-08-28 | — | — | US | disclosed |
| EP-0975594-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | Pfizer Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1999002493-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |