Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758953 | 0.85 | CDK4 (0.58) | CDK4GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7476741 | 0.81 | NR4A2 (0.61) | NR4A2GABRA1GABRA3GABRB2GABRB1 | |
| SCHEMBL5434549 | 0.76 | NR4A2 (0.69) | NR4A2GABRA1GABRA3GABRB2GABRB1 | |
| SCHEMBL3130492 | 0.76 | NR4A2 (0.55) | NR4A2GABRA1GABRA3GABRB2GABRB1 | |
| SCHEMBL1557691 | 0.75 | NR4A2 (0.63) | NR4A2GABRA1GABRA3GABRB2GABRB1 | |
| SCHEMBL31127577 | 0.75 | NR4A2 (0.63) | NR4A2GABRA1GABRA3GABRB2GABRB1 | |
| SCHEMBL13896416 | 0.74 | NPC1 (0.74) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL3130989 | 0.74 | NR4A2 (0.52) | NR4A2GABRA1GABRB2 | |
| SCHEMBL10104626 | 0.74 | NR4A2 (0.52) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL2085712 | 0.73 | NR4A2 (0.69) | NR4A2GABRA1GABRA3GABRB2GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |