Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418494 | 1.00 | MAPT (0.44) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL7475969 | 0.90 | ALOX5AP (0.43) | TP53ALDH1A1DPP4L3MBTL1MEN1 | |
| SCHEMBL7424396 | 0.90 | ALOX5AP (0.43) | TP53ALDH1A1DPP4L3MBTL1MEN1 | |
| SCHEMBL7427376 | 0.89 | ALOX5AP (0.44) | TP53ALDH1A1DPP4L3MBTL1LMNA | |
| SCHEMBL7471120 | 0.89 | ALOX5AP (0.44) | TP53ALDH1A1DPP4L3MBTL1LMNA | |
| SCHEMBL7471087 | 0.85 | L3MBTL1 (0.49) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL7468891 | 0.84 | MAPT (0.44) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL7418990 | 0.84 | MAPT (0.44) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL7415932 | 0.83 | MAPT (0.43) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL7425401 | 0.82 | MAPT (0.43) | MAPTTP53ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |