Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785273 | 1.00 | MAOA (0.39) | MAOAMAOBIRAK4CDK1CDK2 | |
| SCHEMBL5785267 | 1.00 | MAOA (0.39) | MAOAMAOBIRAK4CDK1CDK2 | |
| SCHEMBL4485044 | 0.90 | KMT2A (0.35) | IRAK4CDK1CDK2CDC42BPACDK5 | |
| SCHEMBL4485046 | 0.90 | KMT2A (0.35) | IRAK4CDK1CDK2CDC42BPACDK5 | |
| SCHEMBL4494272 | 0.90 | GAA (0.38) | KMT2ATSHRMEN1MAPTHTT | |
| SCHEMBL4484962 | 0.90 | BACE1 (0.38) | KMT2AKDRFLT3TSHRKIT | |
| SCHEMBL2564367 | 0.90 | KMT2A (0.37) | KMT2AKDRFLT3TSHRKIT | |
| SCHEMBL4494278 | 0.90 | GAA (0.38) | KMT2ATSHRMEN1MAPTHTT | |
| SCHEMBL2564369 | 0.90 | KMT2A (0.37) | KMT2AKDRFLT3TSHRKIT | |
| SCHEMBL4484967 | 0.90 | BACE1 (0.38) | KMT2AKDRFLT3TSHRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |