Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | F2 | P00734 | 6/20 | 0.46 |
| ▸ | F10 | P00742 | 6/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486939 | 0.94 | CHEK2 (0.48) | CHEK2GPR119F2F10PDE4D | |
| SCHEMBL7484425 | 0.92 | CHEK2 (0.51) | CHEK2GPR119F2F10PDE4D | |
| SCHEMBL7482886 | 0.88 | CHEK2 (0.49) | CHEK2GPR119F2F10PDE4D | |
| SCHEMBL7486430 | 0.85 | CHEK2 (0.53) | CHEK2GPR119PDE4DPDE4APDE4B | |
| SCHEMBL7481944 | 0.84 | CHEK2 (0.52) | CHEK2GPR119F2F10PDE4D | |
| SCHEMBL7481010 | 0.83 | CHEK2 (0.51) | CHEK2GPR119F2F10HRH3 | |
| SCHEMBL7482431 | 0.83 | GPR119 (0.52) | CHEK2GPR119HRH3 | |
| SCHEMBL7483410 | 0.79 | GPR119 (0.45) | CHEK2GPR119F2F10PDE4D | |
| SCHEMBL7473742 | 0.77 | CNR2 (0.41) | — | |
| SCHEMBL7475707 | 0.76 | GPR119 (0.52) | CHEK2GPR119PDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |