Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.64 |
| ▸ | NOS3 | P29474 | 2/20 | 0.59 |
| ▸ | NOS1 | P29475 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483877 | 0.90 | SLC6A4 (0.64) | SLC6A4NOS3NOS1 | |
| SCHEMBL7486116 | 0.87 | SLC6A4 (0.63) | SLC6A4NOS3NOS1 | |
| SCHEMBL7478687 | 0.86 | NOS3 (0.69) | SLC6A4NOS3NOS1 | |
| SCHEMBL7485764 | 0.83 | SLC6A4 (0.63) | SLC6A4NOS3NOS1 | |
| SCHEMBL7480892 | 0.81 | NOS3 (0.68) | SLC6A4NOS3NOS1 | |
| SCHEMBL7484094 | 0.81 | NOS3 (0.83) | SLC6A4NOS3NOS1 | |
| SCHEMBL8382132 | 0.80 | HTR1D (0.40) | SLC6A4NOS3NOS1 | |
| SCHEMBL4673448 | 0.80 | SLC6A4 (1.00) | SLC6A4 | |
| SCHEMBL7480641 | 0.79 | NOS3 (0.69) | SLC6A4NOS3NOS1 | |
| SCHEMBL8607603 | 0.79 | SLC6A4 (0.77) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733628-B9 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-0733628-B1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5962474-A | ANALGESICS; HEADACHES | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5708008-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| WO-1996029075-A1 | 5-SUBSTITUTED-3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)- AND 3-(PIPERIDIN-4-YL)-1H-INDOLES: NEW 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0733628-A1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists | ELI LILLY AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |