Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475712 | 0.92 | MEN1 (0.50) | KMT2ANPC1MEN1BLMPTPN1 | |
| SCHEMBL7429153 | 0.90 | MEN1 (0.49) | KMT2ANPC1MEN1BLMPTPN1 | |
| SCHEMBL7427489 | 0.84 | MEN1 (0.58) | KMT2ANPC1MEN1PTPN1MAPT | |
| SCHEMBL7487945 | 0.83 | BLM (0.61) | KMT2ANPC1MEN1BLMPTPN1 | |
| SCHEMBL7426341 | 0.81 | MEN1 (0.59) | KMT2ANPC1MEN1PTPN1MAPT | |
| SCHEMBL7478654 | 0.80 | BLM (0.61) | KMT2ANPC1MEN1BLMMAPT | |
| SCHEMBL7481487 | 0.78 | BLM (0.59) | KMT2ANPC1MEN1BLMMAPT | |
| SCHEMBL7479019 | 0.78 | RAB9A (0.61) | KMT2ANPC1MEN1PTPN1MAPT | |
| SCHEMBL7423143 | 0.78 | MEN1 (0.62) | KMT2ANPC1MEN1PTPN1MAPT | |
| SCHEMBL7482056 | 0.78 | BLM (0.58) | KMT2ANPC1MEN1BLMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |