Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | ESRRB | O95718 | 1/20 | 0.34 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473742 | 0.90 | CNR2 (0.41) | HTR6ESR2NR1H2NR1H3ESR1 | |
| SCHEMBL7486828 | 0.88 | CNR2 (0.43) | HTR6ESR2NR1H2ESR1 | |
| SCHEMBL7482600 | 0.86 | CNR2 (0.41) | HTR6ESR2NR1H2NR1H3 | |
| SCHEMBL7476588 | 0.84 | HTR6 (0.38) | HTR6ESR2NR1H2NR1H3 | |
| SCHEMBL23448942 | 0.83 | HTR6 (0.35) | HTR6ESR2NR1H2NR1H3 | |
| SCHEMBL14300652 | 0.83 | CYP1A2 (0.46) | NR1H2NR1H3 | |
| SCHEMBL7480954 | 0.83 | ESR2 (0.41) | HTR6ESR2NR1H2NR1H3GABRG2 | |
| SCHEMBL7483480 | 0.82 | CNR2 (0.41) | HTR6ESR2NR1H2NR1H3ACSS2 | |
| SCHEMBL7482978 | 0.80 | ESR2 (0.39) | HTR6ESR2NR1H2ACSS2GABRG2 | |
| SCHEMBL7486188 | 0.80 | CNR2 (0.39) | HTR6ESR2NR1H2NR1H3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |