SCHEMBL7477902

SCHEMBL7477902

c1ccc(N2CCN(Cc3nsc4nc5ccccc5n34)CC2)nc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 3/20 0.64
DRD4 P21917 6/20 0.50
DRD2 P14416 3/20 0.50
KDM4E B2RXH2 5/20 0.49
ALDH1A1 P00352 4/20 0.49
CYP3A4 P08684 1/20 0.49
ALOX15 P16050 1/20 0.49
OPRK1 P41145 1/20 0.49
SIGMAR1 Q99720 1/20 0.49
TDP1 Q9NUW8 1/20 0.46
TSHR P16473 1/20 0.46
HSD17B10 Q99714 1/20 0.46
ALOX12 P18054 1/20 0.45
MAPK1 P28482 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.44
DRD3 P35462 2/20 0.44
HTR1A P08908 1/20 0.44
ADRA2A P08913 1/20 0.44
ADRA2B P18089 1/20 0.44
ADRA2C P18825 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7477891 0.89 GRM2 (0.49) GRM2DRD4DRD2KDM4EALDH1A1
SCHEMBL7475139 0.85 GRM2 (0.62) GRM2DRD4DRD2KDM4EALDH1A1
SCHEMBL7475105 0.83 GRM2 (0.43) GRM2DRD4KDM4EMAPK1SMN1; SMN2
SCHEMBL7479275 0.82 TSHR (0.50) GRM2DRD4DRD2KDM4EALDH1A1
SCHEMBL7474510 0.81 KDM4E (0.48) GRM2DRD4DRD2KDM4ETSHR
SCHEMBL7477326 0.81 MEN1 (0.52) GRM2DRD4KDM4EALDH1A1CYP3A4
SCHEMBL7473319 0.81 GRM2 (0.51) GRM2DRD4KDM4EALDH1A1TSHR
SCHEMBL7477813 0.79 KDM4E (0.49) GRM2DRD4DRD2KDM4ETSHR
SCHEMBL7471278 0.79 KDM4E (0.58) GRM2DRD4DRD2KDM4EALDH1A1
SCHEMBL7474146 0.79 HPGD (0.59) GRM2KDM4EALDH1A1TDP1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0883622-B1 PROTON PUMP INHIBITOR APOTEX INC (CA) 2002-05-15 EP claimed
EP-0883606-A1 PROCESS FOR SCAVENGING THIOLS APOTEX INC. (CA) 1998-12-16 EP claimed
WO-1997031893-A1 PROCESS FOR SCAVENGING THIOLS APOTEX INC. (CA) 1997-09-04 WO claimed
EP-0883622-B1 PROTON PUMP INHIBITOR APOTEX INC (CA) 2002-05-15 EP disclosed
US-6114537-A 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS APOTEX INC. (CA) 2000-09-05 US disclosed
US-6093738-A IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT KARIMIAN KHASHAYAR (CA) 2000-07-25 US disclosed
EP-0883622-A1 PROTON PUMP INHIBITOR APOTEX INC. (CA) 1998-12-16 EP disclosed
EP-0883606-A1 PROCESS FOR SCAVENGING THIOLS APOTEX INC. (CA) 1998-12-16 EP disclosed
WO-1997031923-A1 PROTON PUMP INHIBITOR APOTEX INC. (CA) 1997-09-04 WO disclosed
WO-1997031893-A1 PROCESS FOR SCAVENGING THIOLS APOTEX INC. (CA) 1997-09-04 WO disclosed