Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.57 |
| ▸ | ACE | P12821 | 7/20 | 0.55 |
| ▸ | CPA1 | P15085 | 3/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418789 | 0.93 | MME (0.54) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL8387195 | 0.87 | MME (0.65) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL7374244 | 0.85 | MME (0.57) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL8390537 | 0.83 | MME (0.63) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL7384919 | 0.83 | MME (0.63) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL8764113 | 0.83 | MME (0.63) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL7344017 | 0.83 | MME (0.55) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL7382939 | 0.82 | MME (0.61) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL8385738 | 0.82 | MME (0.61) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL7337403 | 0.82 | MME (0.60) | MMEACECPA1ACE2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1047450-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |
| WO-1999032150-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |