Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 3/20 | 0.56 |
| ▸ | CPA1 | P15085 | 1/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 2/20 | 0.55 |
| ▸ | REN | P00797 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595012 | 0.90 | MMP1 (0.66) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL7374244 | 0.88 | MME (0.57) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL10662173 | 0.86 | MME (0.58) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL7344017 | 0.86 | MME (0.55) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL3910340 | 0.85 | MME (0.66) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL17026706 | 0.85 | MME (0.66) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL10932308 | 0.85 | MME (0.66) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL8390276 | 0.83 | MME (0.68) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL15649671 | 0.83 | MME (0.67) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL15692372 | 0.83 | MME (0.67) | MMEMMP2MMP7MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844877-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| EP-0826000-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | Chiroscience Limited (GB) | 1998-03-04 | — | — | EP | disclosed |
| EP-0783500-A1 | AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS | ZENECA LIMITED (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1997006802-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1997-02-27 | — | — | WO | disclosed |
| WO-1996035714-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | CHIROSCIENCE LIMITED (GB) | 1996-11-14 | — | — | WO | disclosed |
| WO-1996010022-A1 | AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS | ZENECA LIMITED (GB) | 1996-04-04 | — | — | WO | disclosed |