Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexpramipexole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 1.00 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 1.00 |
| ▸ | HRH2 | P25021 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | HTR1B | P28222 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR7 | P34969 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.56 |
| ▸ | SCN4A | P35499 | 4/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramipexole SCHEMBL195775 | 1.00 | DRD3 (1.00) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL35376 | 1.00 | DRD3 (1.00) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL2995942 | 0.99 | ADRA2A (1.00) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL1193565 | 0.99 | DRD3 (0.97) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4144177 | 0.99 | DRD3 (0.97) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4099920 | 0.99 | ADRA2A (1.00) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL3947668 | 0.99 | DRD3 (0.97) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL42113 | 0.99 | ADRA2A (1.00) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL20524815 | 0.99 | DRD3 (0.97) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Dexpramipexole SCHEMBL910147 | 0.99 | ADRA2A (1.00) | DRD3DRD2HRH2ADRA2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9883 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-20260096574-A1 | CHOCOLATE REPLICAS PRODUCED FROM INDIVIDUAL COMPONENTS | VOYAGE FOODS INC (US) | 2026-04-09 | — | — | US | claimed |
| EP-4717276-A2 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | University of Canberra (AU) | 2026-04-01 | — | — | EP | claimed |
| EP-4696684-A1 | DEHYDRATION AND HYDROGENATION PROCESS OF BIOMASS FEEDSTOCK FOR PREPARING FURANIC INTERMEDIATES | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO (NL) | 2026-02-18 | — | — | EP | claimed |
| EP-3615024-B1 | COMPOSITIONS COMPRISING PRAMIPEXOLE AND A 5HT3 ANTAGONIST FOR USE IN TREATING DEPRESSION | ALTO NEUROSCIENCE INC (US) | 2026-02-18 | — | — | EP | claimed |
| US-20260028562-A1 | FLAVORED POROUS MATERIAL FOR FLAVORED BEVERAGE PRODUCTION | DANSTAR FERMENT AG (CH) | 2026-01-29 | — | — | US | claimed |
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| US-20260021077-A1 | USE OF DEXPRAMIPEXOLE FOR THE TREATMENT OF MODERATE TO SEVERE ASTHMA | ARETEIA THERAPEUTICS, INC. (US) | 2026-01-22 | — | — | US | claimed |
| US-20260007144-A1 | CHOCOLATE REPLICAS PRODUCED FROM INDIVIDUAL COMPONENTS | VOYAGE FOODS INC (US) | 2026-01-08 | — | — | US | claimed |
| US-20260000910-A1 | METHOD FOR TREATING PARKINSON'S DISEASE THROUGH PHOTOSTIMULATION, AND DEVICE USED IN SAID METHOD | TSUBOTA LAB INC (JP) | 2026-01-01 | — | — | US | claimed |
| CN-1032548-A | Reduce the method for nitrogen oxide in the waste gas | FUEL TECH INC (US) | 1989-04-26 | — | — | CN | claimed |
| WO-1989003242-A2 | PROCESS FOR THE REDUCTION OF NITROGEN OXIDES IN AN EFFLUENT | FUEL TECH, INC. (US) | 1989-04-20 | — | — | WO | claimed |
| WO-1989002781-A2 | PROCESS FOR NITROGEN OXIDES REDUCTION AND MINIMIZATION OF THE PRODUCTION OF OTHER POLLUTANTS | FUEL TECH, INC. (US) | 1989-04-06 | — | — | WO | claimed |
| WO-1989002780-A2 | MULTI-STAGE PROCESS FOR REDUCING THE CONCENTRATION OF POLLUTANTS IN AN EFFLUENT | FUEL TECH, INC. (US) | 1989-04-06 | — | — | WO | claimed |
| EP-0304478-A1 | PROCESS FOR NITROGEN OXIDES REDUCTION WITH MINIMIZATION OF THE PRODUCTION OF OTHER POLLUTANTS. | FUEL TECH INC (US) | 1989-03-01 | — | — | EP | claimed |
| WO-1988006487-A1 | PROCESS FOR NITROGEN OXIDES REDUCTION WITH MINIMIZATION OF THE PRODUCTION OF OTHER POLLUTANTS | FUEL TECH, INC. (US) | 1988-09-07 | — | — | WO | claimed |
| US-4529992-A | Multicolor record material | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1985-07-16 | — | — | US | claimed |
| US-4339245-A | GASOLINE, ANTIKNOCK COMPOUNDS | PHILLIPS PETROLEUM COMPANY (US) | 1982-07-13 | — | — | US | claimed |
| US-4256851-A | Degradable plastic composition containing unsaturated alcohol or ester thereof | OWENS-ILLINOIS, INC. (US) | 1981-03-17 | — | — | US | claimed |
| US-4045453-A | Method for producing 5-nitro-2-furfuryl acetate | KEMIRA OY (SF) | 1977-08-30 | — | — | US | claimed |