Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483184 | 0.89 | CHEK2 (0.45) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL7478041 | 0.88 | KCNH2 (0.47) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL7478915 | 0.83 | CHEK2 (0.44) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL7478925 | 0.83 | CHEK2 (0.44) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL7483176 | 0.80 | KCNH2 (0.50) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL2501011 | 0.75 | PDE4B (0.46) | GPR119PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5970629 | 0.74 | ALDH1A1 (0.51) | GPR119PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7484248 | 0.73 | CHEK2 (0.46) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL7484242 | 0.73 | CHEK2 (0.46) | CHEK2GPR119KCNH2PDE4DPDE4B | |
| SCHEMBL20567634 | 0.73 | KDM1A (0.52) | GPR119PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |