Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 6/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.37 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978214 | 0.94 | AVPR2 (0.33) | AVPR2AVPR1AAVPR1BIRAK4RAB9A | |
| SCHEMBL7964705 | 0.86 | AVPR2 (0.36) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| SCHEMBL7962075 | 0.85 | MAP3K7 (0.39) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| Hydrochloric Acid SCHEMBL7954696 | 0.84 | MAP3K7 (0.39) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| SCHEMBL7970647 | 0.83 | MAP3K7 (0.38) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| SCHEMBL7966800 | 0.83 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| SCHEMBL7966116 | 0.83 | MAP3K7 (0.38) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| Hydrochloric Acid SCHEMBL7954456 | 0.83 | MAP3K7 (0.38) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 | |
| SCHEMBL7475627 | 0.82 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BMAP3K7PTK2 | |
| SCHEMBL7975598 | 0.82 | HDAC8 (0.44) | AVPR2AVPR1AAVPR1BIRAK4MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |