Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.60 |
| ▸ | HTR3A | P46098 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478614 | 1.00 | CHRNA7 (0.60) | CHRNA7HTR3ANPC1RAB9AYTHDC1 | |
| SCHEMBL12441910 | 0.82 | CHRNA7 (0.64) | CHRNA7HTR3ANPC1RAB9AYTHDC1 | |
| SCHEMBL2086156 | 0.82 | CHRNA7 (0.64) | CHRNA7HTR3ANPC1RAB9AYTHDC1 | |
| SCHEMBL2086084 | 0.81 | NPC1 (0.67) | CHRNA7HTR3ANPC1RAB9ASMYD3 | |
| SCHEMBL7422074 | 0.81 | NPC1 (0.49) | CHRNA7HTR3ANPC1RAB9AYTHDC1 | |
| SCHEMBL2089327 | 0.80 | CHRNA7 (0.64) | CHRNA7HTR3ANPC1RAB9AYTHDC1 | |
| SCHEMBL12441936 | 0.77 | NPC1 (0.68) | CHRNA7HTR3ANPC1RAB9ASMYD3 | |
| SCHEMBL2086948 | 0.77 | NPC1 (0.68) | CHRNA7HTR3ANPC1RAB9ASMYD3 | |
| SCHEMBL2087490 | 0.77 | NPC1 (0.68) | CHRNA7HTR3ANPC1RAB9ASMYD3 | |
| SCHEMBL29732688 | 0.76 | NPC1 (0.74) | CHRNA7HTR3ANPC1RAB9ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117882-A | 5-HT4 agonists and antagonists | ELI LILLY AND COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| US-6069152-A | NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| WO-1999017772-A1 | 5HT4 AGONISTS AND ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| EP-0908459-A1 | 5-HT4 Agonists and antagonists | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |