Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | HTR3A | P46098 | 10/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.64 |
| ▸ | HTR3B | O95264 | 2/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.64 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.64 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086948 | 1.00 | NPC1 (0.68) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| SCHEMBL12441936 | 1.00 | NPC1 (0.68) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| SCHEMBL2086084 | 0.95 | NPC1 (0.67) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| SCHEMBL19236410 | 0.91 | NPC1 (0.62) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| Trifluoroacetic Acid SCHEMBL17163423 | 0.89 | NPC1 (0.60) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| Trifluoroacetic Acid SCHEMBL17163426 | 0.89 | NPC1 (0.60) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| Indisetron SCHEMBL18311525 | 0.89 | NPC1 (0.61) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| SCHEMBL7345995 | 0.89 | NPC1 (0.61) | NPC1RAB9AHTR3AHTR3EHTR3B | |
| SCHEMBL8713946 | 0.89 | NPC1 (0.61) | NPC1RAB9AHTR3AGSK3BDYRK1A | |
| SCHEMBL7339115 | 0.89 | NPC1 (0.61) | NPC1RAB9AHTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498466-B1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | EP | claimed |
| EP-0498466-A1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | BEECHAM GROUP PLC (GB) | 1992-08-12 | — | — | EP | claimed |
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2011-07-21 | — | — | US | disclosed |
| US-7902217-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20090118232-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2009-05-07 | — | — | US | disclosed |
| US-7488737-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080139609-A1 | GRANISETRON COMPOSITIONS | DR. REDDY'S LABORATORIES, INC. | 2008-06-12 | — | — | US | disclosed |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION | 2005-11-10 | — | — | US | disclosed |
| EP-0498466-B1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | EP | disclosed |
| US-5034398-A | Analgesics | BEECHAM GROUP P.L.C. (GB) | 1991-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | NPC1 622/4885RAB9A 2787/4885HTR3A 61/4885 |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | CHRNA7, CHRNA5, CHRNA2 | NPC1 622/4885RAB9A 2787/4885HTR3A 61/4885 |
| US-20080139609-A1 | GRANISETRON COMPOSITIONS | GCG, GCGR, MC2R | NPC1 2172/4885RAB9A 963/4885HTR3A 11/4885 |
| US-20090118232-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | NPC1 622/4885RAB9A 2787/4885HTR3A 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.