Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348423 | 0.91 | NPC1 (0.53) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL6203813 | 0.84 | ALDH1A1 (0.65) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL4843293 | 0.82 | ALDH1A1 (0.60) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL20157900 | 0.82 | MAPT (0.58) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL10952466 | 0.82 | HTT (0.58) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL31366556 | 0.82 | HTT (0.58) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL4456955 | 0.81 | NPC1 (0.59) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL20157807 | 0.81 | NPC1 (0.59) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL20157317 | 0.80 | NPC1 (0.58) | HTTMAPTNPSR1KMT2ANPC1 | |
| SCHEMBL3638432 | 0.80 | HPGD (0.72) | HTTMAPTNPSR1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683774-B1 | HYPOLIPIDAEMIC COMPOUNDS | WELLCOME FOUND (GB) | 2002-10-09 | — | — | EP | disclosed |
| US-5723458-A | 1,4-BENZOTHIAZEPINES | GLAXO WELLCOME INC. (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0683774-A1 | HYPOLIPIDAEMIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018184-A1 | HYPOLIPIDAEMIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |