Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20929269 | 0.93 | NR1H2 (0.64) | NR1H2ESR2MAPK1NPC1RAB9A | |
| SCHEMBL7477263 | 0.79 | USP30 (0.51) | NR1H2ESR2NPC1RAB9AGPR119 | |
| SCHEMBL26845053 | 0.79 | ESR2 (0.61) | NR1H2ESR2MAPK1NPC1RAB9A | |
| SCHEMBL4638117 | 0.79 | NR1H2 (0.54) | NR1H2ESR2NPC1RAB9AGPR119 | |
| SCHEMBL26844994 | 0.79 | NR1H2 (0.63) | NR1H2ESR2MAPK1HDAC1DDB1 | |
| SCHEMBL8259553 | 0.79 | MAPT (0.46) | MAPK1NPC1GPR119MAPTTHRB | |
| SCHEMBL29506996 | 0.79 | NR1H2 (0.63) | NR1H2ESR2MAPK1HDAC1DDB1 | |
| SCHEMBL20929548 | 0.78 | NR1H2 (0.65) | NR1H2ESR2MAPK1NPC1RAB9A | |
| SCHEMBL2306894 | 0.77 | NR1H2 (0.85) | NR1H2ESR2MAPK1NPC1RAB9A | |
| SCHEMBL8561292 | 0.77 | ESR2 (0.50) | NR1H2ESR2NPC1RAB9AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |