Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | KHK | P50053 | 4/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478863 | 0.79 | NR1H2 (0.54) | USP30NR1H2ESR2NPC1RAB9A | |
| SCHEMBL3607083 | 0.78 | USP30 (0.52) | USP30NR1H2ESR2NPC1RAB9A | |
| SCHEMBL5458949 | 0.77 | ESR2 (0.52) | NR1H2ESR2NPC1RAB9AKDM4E | |
| SCHEMBL7419930 | 0.77 | NR1H2 (0.49) | USP30NR1H2ESR2NPC1RAB9A | |
| SCHEMBL4638117 | 0.76 | NR1H2 (0.54) | NR1H2ESR2NPC1RAB9AKDM4E | |
| SCHEMBL7473247 | 0.75 | NR1H2 (0.47) | USP30NR1H2ESR2NPC1RAB9A | |
| SCHEMBL20929267 | 0.75 | NR1H2 (0.64) | USP30NR1H2ESR2NPC1RAB9A | |
| SCHEMBL6671296 | 0.75 | HRH3 (0.57) | NR1H2ESR2NPC1RAB9AGPR119 | |
| SCHEMBL14335350 | 0.75 | DDB1 (0.46) | NPC1RAB9AKDM4EMAPTTHRB | |
| Hydrochloric Acid SCHEMBL7472741 | 0.74 | ACHE (0.41) | USP30KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |