Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.57 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478954 | 0.78 | GRIN2D (0.45) | HRH3GRIN1GRIN2BL3MBTL1 | |
| SCHEMBL7481724 | 0.77 | DRD1 (0.48) | — | |
| SCHEMBL8188071 | 0.75 | HRH3 (0.92) | HRH3CARM1CYP2D6HRH1REV1 | |
| SCHEMBL5450398 | 0.74 | HRH3 (1.00) | HRH3CARM1CYP2D6HRH1 | |
| Hydrochloric Acid SCHEMBL4937090 | 0.72 | HRH3 (0.97) | HRH3CARM1CYP2D6HRH1 | |
| SCHEMBL3045956 | 0.72 | REV1 (0.70) | HRH3CARM1CYP2D6HRH1REV1 | |
| SCHEMBL7478927 | 0.72 | HRH3 (0.56) | HRH3CARM1CYP2D6HRH1REV1 | |
| SCHEMBL4917832 | 0.70 | HRH3 (0.77) | HRH3CARM1CYP2D6HRH1REV1 | |
| SCHEMBL8539582 | 0.70 | SLC6A2 (0.57) | — | |
| SCHEMBL9194405 | 0.70 | HRH3 (0.53) | HRH3CYP2D6HRH1REV1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |