Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 3/20 | 0.45 |
| ▸ | GHSR | Q92847 | 5/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585505 | 0.87 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7465912 | 0.86 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL3357221 | 0.86 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7475438 | 0.85 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL14960188 | 0.85 | CHRNB2 (0.42) | PRMT5CHRNB2CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL3356276 | 0.84 | CHRNB2 (0.42) | PRMT5CHRNB2CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL13308501 | 0.84 | CHRNB2 (0.42) | PRMT5CHRNB2CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL2185544 | 0.84 | CHRNB2 (0.45) | PRMT5CHRNB2CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL3358832 | 0.84 | CHRNB2 (0.42) | PRMT5CHRNB2CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL16194984 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1125064-C | 3-pyridyl enantiomers and their use as analgesics | ABBOTT LAB (US) | 2003-10-22 | — | — | CN | disclosed |
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6403575-B1 | ANTI-INFLAMMATORIES | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| US-6133253-A | NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| CN-1245496-A | 3-pyridyl enantiomers and their use as analgesics | ABBOTT LAB (US) | 2000-02-23 | — | — | CN | disclosed |